The coronavirus disease 2019 (COVID-19) pandemic has stressed the importance of health research as never before.
In the specific domain of clinical research, the effort to rapidly find responses to health challenges and therapeutic
hypotheses has highlighted the need for efficient, timely, ethically correct research. The guidelines published by the
Agenzia Italiana del Farmaco have shown that some useful changes are feasible: simple and rapid methods have been
implemented to conduct clinical research in the emergency conditions of the pandemic, maintaining high levels of quality.
In this perspective, four Italian scientific associations operating in clinical research have worked together to evaluate
which measures, among the ones implemented during the pandemic, have been particularly significant and potentially
effective under normal conditions or in case of emergencies, and that therefore will be useful in the future as well.

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